| 04/13/2022 | Giants | Angels | 6:00PM - 7:15PM | Maryville Little League / Field 1 | Rescheduled |
| 04/13/2022 | Braves | Tigers | 7:30PM - 8:45PM | Maryville Little League / Field 1 | Rescheduled |
| 04/15/2022 | Giants | Braves | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 04/15/2022 | Cubs | Rays | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 04/20/2022 | Cubs | Giants | 6:00PM - 7:15PM | Maryville Little League / Field 1 | Rescheduled |
| 04/20/2022 | Tigers | Rays | 6:00PM - 7:15PM | Maryville Little League / Field 3 | Rescheduled |
| 04/20/2022 | Angels | Braves | 7:30PM - 8:45PM | Maryville Little League / Field 1 | Rescheduled |
| 04/22/2022 | Cubs | Tigers | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 04/22/2022 | Angels | Rays | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 04/23/2022 | Rays | Cubs | 12:45PM - 2:00PM | Maryville Little League / Field 1 | |
| 04/23/2022 | Angels | Giants | 2:15PM - 3:30PM | Maryville Little League / Field 1 | |
| 04/23/2022 | Tigers | Braves | 3:45PM - 5:15PM | Maryville Little League / Field 1 | |
| 04/29/2022 | Angels | Cubs | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 04/29/2022 | Rays | Giants | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 04/30/2022 | Tigers | Cubs | 12:45PM - 2:00PM | Maryville Little League / Field 1 | |
| 04/30/2022 | Rays | Angels | 2:15PM - 3:30PM | Maryville Little League / Field 1 | |
| 04/30/2022 | Braves | Giants | 3:45PM - 5:15PM | Maryville Little League / Field 1 | |
| 05/01/2022 | Rays | Braves | 1:00PM - 2:15PM | Maryville Little League / Field 1 | Rescheduled |
| 05/01/2022 | Tigers | Giants | 2:30PM - 3:45PM | Maryville Little League / Field 1 | Rescheduled |
| 05/01/2022 | Cubs | Angels | 4:00PM - 5:15PM | Maryville Little League / Field 1 | Rescheduled |
| 05/13/2022 | Tigers | Rays | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 05/13/2022 | Angels | Braves | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 05/14/2022 | Giants | Angels | 12:45PM - 2:00PM | Maryville Little League / Field 1 | |
| 05/14/2022 | Rays | Braves | 2:15PM - 3:30PM | Maryville Little League / Field 1 | |
| 05/14/2022 | Cubs | Tigers | 3:45PM - 5:15PM | Maryville Little League / Field 1 | |
| 05/20/2022 | Tigers | Giants | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 05/20/2022 | Cubs | Braves | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 05/21/2022 | Giants | Cubs | 12:45PM - 2:00PM | Maryville Little League / Field 1 | |
| 05/21/2022 | Braves | Tigers | 2:15PM - 3:30PM | Maryville Little League / Field 1 | |
| 05/21/2022 | Angels | Rays | 3:45PM - 5:15PM | Maryville Little League / Field 1 | |
| 05/22/2022 | Braves | Cubs | 4:45PM - 6:00PM | Maryville Little League / Field 1 | Rescheduled |
| 05/25/2022 | Braves | Angels | 6:00PM - 7:15PM | Maryville Little League / Field 1 | Rescheduled |
| 05/25/2022 | Giants | Cubs | 7:30PM - 8:45PM | Maryville Little League / Field 1 | Rescheduled |
| 05/27/2022 | Braves | Rays | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 05/27/2022 | Angels | Tigers | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |
| 05/28/2022 | Rays | Tigers | 12:45PM - 2:00PM | Maryville Little League / Field 1 | |
| 05/28/2022 | Braves | Giants | 2:15PM - 3:30PM | Maryville Little League / Field 1 | |
| 05/28/2022 | Cubs | Angels | 3:45PM - 5:15PM | Maryville Little League / Field 1 | |
| 06/01/2022 | Giants | Rays | 6:00PM - 7:15PM | Maryville Little League / Field 1 | Rescheduled |
| 06/01/2022 | Tigers | Angels | 7:30PM - 8:45PM | Maryville Little League / Field 1 | Rescheduled |
| 06/03/2022 | Rays | Cubs | 6:00PM - 7:15PM | Maryville Little League / Field 1 | |
| 06/03/2022 | Giants | Tigers | 7:30PM - 8:45PM | Maryville Little League / Field 1 | |